diff --git a/src/Shentun.Peis.Application/RegisterChecks/RegisterCheckAppService.cs b/src/Shentun.Peis.Application/RegisterChecks/RegisterCheckAppService.cs
index 751d5f1..8fe18e6 100644
--- a/src/Shentun.Peis.Application/RegisterChecks/RegisterCheckAppService.cs
+++ b/src/Shentun.Peis.Application/RegisterChecks/RegisterCheckAppService.cs
@@ -278,7 +278,16 @@ namespace Shentun.Peis.RegisterChecks
             {
                 throw new UserFriendlyException("input参数不能为空");
             }
-            var registerCheck = await _registerCheckRepository.GetAsync(input.RegisterCheckId);
+            if (input.RegisterCheckItems == null)
+            {
+                throw new UserFriendlyException("RegisterCheckItems参数不能为空");
+            }
+            if(!input.RegisterCheckItems.Where(o=>!string.IsNullOrWhiteSpace(o.Result)).ToList().Any())
+            {
+                throw new UserFriendlyException("明细结果不能全部为空");
+            }
+
+             var registerCheck = await _registerCheckRepository.GetAsync(input.RegisterCheckId);
             var patientRegister = await _patientRegisterRepository.GetAsync(registerCheck.PatientRegisterId);
             //修改医生和检查日期
             if(string.IsNullOrWhiteSpace(input.CheckDoctorId))
diff --git a/src/Shentun.Peis.Domain/RegisterCheckAsbitems/RegisterCheckAsbitemManager.cs b/src/Shentun.Peis.Domain/RegisterCheckAsbitems/RegisterCheckAsbitemManager.cs
index e087f5e..9190d6e 100644
--- a/src/Shentun.Peis.Domain/RegisterCheckAsbitems/RegisterCheckAsbitemManager.cs
+++ b/src/Shentun.Peis.Domain/RegisterCheckAsbitems/RegisterCheckAsbitemManager.cs
@@ -539,6 +539,11 @@ namespace Shentun.Peis.RegisterAsbitems
                         createRegisterCheckAsbitemEntity.DeleteRegisterCheckItems.Add(registerItem);
                     }
                 }
+                //没有检查申请单号的，重新生成检查申请单号
+                if(string.IsNullOrWhiteSpace(registerCheck.CheckRequestNo))
+                {
+                    registerCheck.CheckRequestNo = await _registerCheckManager.CreateCheckRequestNo(patientRegister.MedicalCenterId);
+                }
 
             }
             //获取所有已有的itemtype和checkId