diff --git a/src/Shentun.Peis.Application/AsbitemDetails/AsbitemDetailAppService.cs b/src/Shentun.Peis.Application/AsbitemDetails/AsbitemDetailAppService.cs
index baa13c6..bbb2df3 100644
--- a/src/Shentun.Peis.Application/AsbitemDetails/AsbitemDetailAppService.cs
+++ b/src/Shentun.Peis.Application/AsbitemDetails/AsbitemDetailAppService.cs
@@ -29,11 +29,13 @@ namespace Shentun.Peis.AsbitemDetails
     {
         private readonly IRepository<AsbitemDetail> _repository;
         private readonly IRepository<IdentityUser, Guid> _userRepository;
+        private readonly AsbitemDetailManager _manager;
 
-        public AsbitemDetailAppService(IRepository<AsbitemDetail> repository, IRepository<IdentityUser, Guid> userRepository)
+        public AsbitemDetailAppService(IRepository<AsbitemDetail> repository, IRepository<IdentityUser, Guid> userRepository, AsbitemDetailManager manager)
         {
             this._repository = repository;
             this._userRepository = userRepository;
+            this._manager = manager;
         }
 
         /// <summary>
@@ -59,27 +61,31 @@ namespace Shentun.Peis.AsbitemDetails
         [HttpPost("api/app/asbitemdetail/createasbitemdetailmany")]
         public async Task CreateAsbitemDetailManyAsync(CreateAsbitemDetailDto input)
         {
-
-            await _repository.DeleteAsync(d => d.AsbitemId == input.AsbitemId);
+            await _manager.CheckAndDeleteAsync(input.AsbitemId);
 
             if (input.Details.Any())
             {
-                var createEntity = ObjectMapper.Map<List<CreateAsbitemDetail_Detail>, List<AsbitemDetail>>(input.Details);
-                await _repository.InsertManyAsync(createEntity);
+                List<AsbitemDetail> asbitemDetails = new List<AsbitemDetail>();
+                foreach (var details in input.Details)
+                {
+                    var entity = new AsbitemDetail
+                    {
+                        AsbitemId = input.AsbitemId,
+                        ItemId = details.ItemId
+                    };
+                    asbitemDetails.Add(_manager.CreateAsbitemAsync(entity));
+                }
+
+                if (asbitemDetails.Count > 0)
+                {
+                    await _repository.InsertManyAsync(asbitemDetails);
+                }
+                 
             }
         }
 
 
-        /// <summary>
-        /// 删除
-        /// </summary>
-        /// <param name="AsbitemId"></param>
-        /// <param name="ItemId"></param>
-        /// <returns></returns>
-        public async Task DeleteAsync(Guid AsbitemId, Guid ItemId)
-        {
-            await _repository.DeleteAsync(d => d.AsbitemId == AsbitemId && d.ItemId == ItemId);
-        }
+       
 
 
         /// <summary>
diff --git a/src/Shentun.Peis.Application/AsbitemGuides/AsbitemGuideAppService.cs b/src/Shentun.Peis.Application/AsbitemGuides/AsbitemGuideAppService.cs
index 26421da..928206a 100644
--- a/src/Shentun.Peis.Application/AsbitemGuides/AsbitemGuideAppService.cs
+++ b/src/Shentun.Peis.Application/AsbitemGuides/AsbitemGuideAppService.cs
@@ -22,11 +22,17 @@ namespace Shentun.Peis.AsbitemGuides
     {
         private readonly IRepository<AsbitemGuide> _repository;
         private readonly IRepository<IdentityUser, Guid> _userRepository;
+        private readonly AsbitemGuideManager _manager;
 
-        public AsbitemGuideAppService(IRepository<AsbitemGuide> repository, IRepository<IdentityUser, Guid> userRepository)
+        public AsbitemGuideAppService(
+            IRepository<AsbitemGuide> repository, 
+            IRepository<IdentityUser, Guid> userRepository, 
+            AsbitemGuideManager manager
+            )
         {
             this._repository = repository;
             this._userRepository = userRepository;
+            this._manager = manager;
         }
 
 
@@ -39,7 +45,8 @@ namespace Shentun.Peis.AsbitemGuides
         [HttpPost("api/app/asbitemguide/createasbitemguidemany")]
         public async Task CreateAsbitemGuideManyAsync(CreateAsbitemGuideManyDto input)
         {
-            await _repository.DeleteAsync(d => d.AsbitemId == input.AsbitemId);  //先删除组合项目下的所有信息
+            await _manager.CheckAndDeleteAsync(input.AsbitemId);  //先删除组合项目下的所有信息
+
             if (input.Deatils.Any())
             {
                 List<AsbitemGuide> asbitemGuides = new List<AsbitemGuide>();
@@ -55,8 +62,8 @@ namespace Shentun.Peis.AsbitemGuides
                         Guide = item.Guide,
                         OrganizationUnitId = item.OrganizationUnitId
                     };
-
-                    asbitemGuides.Add(entity);
+                    asbitemGuides.Add(_manager.CreateAsbitemAsync(entity));
+ 
                 }
 
                 await _repository.InsertManyAsync(asbitemGuides);
diff --git a/src/Shentun.Peis.Domain/AsbitemDetails/AsbitemDetailManager.cs b/src/Shentun.Peis.Domain/AsbitemDetails/AsbitemDetailManager.cs
index ac6d054..42e3600 100644
--- a/src/Shentun.Peis.Domain/AsbitemDetails/AsbitemDetailManager.cs
+++ b/src/Shentun.Peis.Domain/AsbitemDetails/AsbitemDetailManager.cs
@@ -1,4 +1,5 @@
-using Shentun.Peis.MedicalPackageDetails;
+using AutoMapper.Internal.Mappers;
+using Shentun.Peis.MedicalPackageDetails;
 using Shentun.Peis.Models;
 using System;
 using System.Collections.Generic;
@@ -22,6 +23,20 @@ namespace Shentun.Peis.AsbitemDetails
             this._repository = repository;
         }
 
+        /// <summary>
+        /// 创建
+        /// </summary>
+        /// <param name="entity"></param>
+        /// <returns></returns>
+        public AsbitemDetail CreateAsbitemAsync(AsbitemDetail entity)
+        {
+            DataHelper.CheckGuidIsDefaultValue(entity.AsbitemId, "组合项目编号");
+            DataHelper.CheckGuidIsDefaultValue(entity.ItemId, "项目编号");
+
+            return entity;
+        }
+
+
         /// <summary>
         /// 删除组合项目明细
         /// </summary>
diff --git a/src/Shentun.Peis.Domain/AsbitemGuides/AsbitemGuideManager.cs b/src/Shentun.Peis.Domain/AsbitemGuides/AsbitemGuideManager.cs
index 66b4e4d..cf19f56 100644
--- a/src/Shentun.Peis.Domain/AsbitemGuides/AsbitemGuideManager.cs
+++ b/src/Shentun.Peis.Domain/AsbitemGuides/AsbitemGuideManager.cs
@@ -5,6 +5,8 @@ using System.Collections.Generic;
 using System.Linq;
 using System.Text;
 using System.Threading.Tasks;
+using TencentCloud.Ame.V20190916.Models;
+using Volo.Abp;
 using Volo.Abp.Domain.Repositories;
 using Volo.Abp.Domain.Services;
 
@@ -22,6 +24,48 @@ namespace Shentun.Peis.AsbitemGuides
         }
 
 
+        /// <summary>
+        /// 创建
+        /// </summary>
+        /// <param name="entity"></param>
+        /// <returns></returns>
+        public AsbitemGuide CreateAsbitemAsync(AsbitemGuide entity)
+        {
+            DataHelper.CheckGuidIsDefaultValue(entity.AsbitemId, "组合项目编号");
+            DataHelper.CheckGuidIsDefaultValue(entity.OrganizationUnitId, "体检中心");
+            if (entity.ForSexId != ForSexFlag.All
+          && entity.ForSexId != ForSexFlag.Male
+          && entity.ForSexId != ForSexFlag.Female
+          )
+            {
+                throw new ArgumentException($"适用性别参数为:{entity.ForSexId},是无效值,只能为'{ForSexFlag.All}','{ForSexFlag.Male}','{ForSexFlag.Female}'");
+            }
+            DataHelper.CheckStringIsNull(entity.Guide, "指引单内容");
+
+            return entity;
+        }
+
+
+        /// <summary>
+        /// 删除指引信息 根据组合项目ID
+        /// </summary>
+        /// <param name="AsbitemId">组合项目ID</param>
+        /// <returns></returns>
+        /// <exception cref="UserFriendlyException"></exception>
+        public async Task CheckAndDeleteAsync(Guid AsbitemId)
+        {
+            var asbitemGuideList = await _asbitemGuideRepository.GetListAsync(m => m.AsbitemId == AsbitemId);
+            if (asbitemGuideList.Any())
+            {
+
+                //删除指引信息
+                await _asbitemGuideRepository.DeleteManyAsync(asbitemGuideList);
+
+            }
+
+        }
+
+
         /// <summary>
         /// 获取指引单内容（根据体检中心、组合项目ID、性别ID）
         /// </summary>
diff --git a/src/Shentun.Peis.Domain/Asbitems/Asbitem.cs b/src/Shentun.Peis.Domain/Asbitems/Asbitem.cs
index f908c27..ca95c57 100644
--- a/src/Shentun.Peis.Domain/Asbitems/Asbitem.cs
+++ b/src/Shentun.Peis.Domain/Asbitems/Asbitem.cs
@@ -118,13 +118,13 @@ namespace Shentun.Peis.Models
         [MaxLength(1)]
         public char IsPictureRotate { get; set; }
         /// <summary>
-        /// 是检查项目
+        /// 是否为检查项目
         /// </summary>
         [Column("is_check")]
         [MaxLength(1)]
         public char IsCheck { get; set; }
         /// <summary>
-        /// 是启用
+        /// 是否启用
         /// </summary>
         [Column("is_active")]
         [MaxLength(1)]
diff --git a/src/Shentun.Peis.Domain/Asbitems/AsbitemManager.cs b/src/Shentun.Peis.Domain/Asbitems/AsbitemManager.cs
index ba7d6ee..1092b3f 100644
--- a/src/Shentun.Peis.Domain/Asbitems/AsbitemManager.cs
+++ b/src/Shentun.Peis.Domain/Asbitems/AsbitemManager.cs
@@ -1,6 +1,7 @@
 using Microsoft.EntityFrameworkCore;
 using Shentun.Peis.AsbitemDetails;
 using Shentun.Peis.CustomerOrgGroupDetails;
+using Shentun.Peis.Enums;
 using Shentun.Peis.HelperDto;
 using Shentun.Peis.MedicalPackageDetails;
 using Shentun.Peis.Models;
@@ -74,7 +75,7 @@ namespace Shentun.Peis.Asbitems
           Asbitem entity
          )
         {
-            DataHelper.CheckStringIsNull(entity.DisplayName, "名称");
+            Verify(entity);
             await EntityHelper.CheckSameName<Asbitem, Guid>(_repository, entity.DisplayName);
             return new Asbitem
             {
@@ -111,10 +112,10 @@ namespace Shentun.Peis.Asbitems
            Asbitem targetEntity
           )
         {
-            DataHelper.CheckStringIsNull(sourceEntity.DisplayName, "名称");
+            DataHelper.CheckEntityIsNull(targetEntity);
+            Verify(sourceEntity);
             if (sourceEntity.DisplayName != targetEntity.DisplayName)
             {
-
                 await EntityHelper.CheckSameName<Asbitem, Guid>(_repository, sourceEntity.DisplayName, targetEntity);
                 targetEntity.DisplayName = sourceEntity.DisplayName;
                 targetEntity.SimpleCode = LanguageConverter.GetPYSimpleCode(targetEntity.DisplayName);
@@ -143,8 +144,33 @@ namespace Shentun.Peis.Asbitems
         }
 
 
+        /// <summary>
+        /// 验证新增、修改字段
+        /// </summary>
+        /// <param name="entity"></param>
+        /// <exception cref="ArgumentException"></exception>
+        private void Verify(Asbitem entity)
+        {
+            DataHelper.CheckEntityIsNull(entity);
+            DataHelper.CheckStringIsNull(entity.DisplayName, "名称");
+            if (entity.ForSexId != ForSexFlag.All
+            && entity.ForSexId != ForSexFlag.Male
+            && entity.ForSexId != ForSexFlag.Female
+            )
+            {
+                throw new ArgumentException($"适用性别参数为:{entity.ForSexId},是无效值,只能为'{ForSexFlag.All}','{ForSexFlag.Male}','{ForSexFlag.Female}'");
+            }
+            DataHelper.CheckGuidIsDefaultValue(entity.ItemTypeId, "项目类别");
+            DataHelper.CheckGuidIsDefaultValue(entity.InvoiceItemTypeId, "发票类别");
+            DataHelper.CheckCharIsYOrN(entity.IsItemResultMerger, "是否合并项目结果");
+            DataHelper.CheckCharIsYOrN(entity.IsBeforeEat, "是否餐前项目");
+            DataHelper.CheckCharIsYOrN(entity.IsDiagnosisFunction, "是否启用诊断函数");
+            DataHelper.CheckCharIsYOrN(entity.IsContinueProcess, "诊断函数处理完毕后继续处理");
+            DataHelper.CheckCharIsYOrN(entity.IsPictureRotate, "体检报告图片旋转90°");
+            DataHelper.CheckCharIsYOrN(entity.IsCheck, "是否为检查项目");
+            DataHelper.CheckCharIsYOrN(entity.IsActive, "是否启用");
+        }
 
-     
 
         /// <summary>
         /// 修改排序  置顶，置底
diff --git a/src/Shentun.Peis.Domain/Items/ItemManager.cs b/src/Shentun.Peis.Domain/Items/ItemManager.cs
index bfa3d0f..4041e81 100644
--- a/src/Shentun.Peis.Domain/Items/ItemManager.cs
+++ b/src/Shentun.Peis.Domain/Items/ItemManager.cs
@@ -149,7 +149,7 @@ namespace Shentun.Peis.Items
                  && entity.ReferenceRangeTypeFlag != ItemReferenceRangeTypeFlag.Character
                  && entity.ReferenceRangeTypeFlag != ItemReferenceRangeTypeFlag.SexHormone)
             {
-                throw new ArgumentException($"参考范围类别参数为:{entity.ReferenceRangeTypeFlag},是无效值,只能为'0','1','2','3'");
+                throw new ArgumentException($"参考范围类别参数为:{entity.ReferenceRangeTypeFlag},是无效值,只能为'{ItemReferenceRangeTypeFlag.None}','{ItemReferenceRangeTypeFlag.Number}','{ItemReferenceRangeTypeFlag.Character}','{ItemReferenceRangeTypeFlag.SexHormone}'");
             }
         }
 
diff --git a/src/Shentun.Peis.Domain/ReferenceRanges/ReferenceRangeManager.cs b/src/Shentun.Peis.Domain/ReferenceRanges/ReferenceRangeManager.cs
index 4f55ec7..f4ecd0e 100644
--- a/src/Shentun.Peis.Domain/ReferenceRanges/ReferenceRangeManager.cs
+++ b/src/Shentun.Peis.Domain/ReferenceRanges/ReferenceRangeManager.cs
@@ -117,7 +117,7 @@ namespace Shentun.Peis.ReferenceRanges
                 && entity.ReferenceRangeTypeFlag != ItemReferenceRangeTypeFlag.SexHormone
                 )
             {
-                throw new ArgumentException($"参考范围类别参数为:{entity.ReferenceRangeTypeFlag},是无效值,只能为'0','1','2','3'");
+                throw new ArgumentException($"参考范围类别参数为:{entity.ReferenceRangeTypeFlag},是无效值,只能为'{ItemReferenceRangeTypeFlag.None}','{ItemReferenceRangeTypeFlag.Number}','2{ItemReferenceRangeTypeFlag.Character}','{ItemReferenceRangeTypeFlag.SexHormone}'");
             }
 
             if (entity.ReferenceRangeTypeFlag == ItemReferenceRangeTypeFlag.Character)